With Cristiano Ronaldo suspended, the Frenchman left Isco and Gareth Bale on the bench — and dropped more points.
A defensive mix-up involving stand-in goalkeeper Kiko Casilla allowed Ivi Lopez to open the scoring in the 12th minute.
Things got worse for Zidane as he lost Karim Benzema to injury, and his replacement Bale continued to struggle in front of goal.
Lucas Vazquez got them on level terms — but they will certainly see it as his two points dropped.
And it got worse still as Marcelo became the third senior player to be dismissed in the opening five matches of the season when he was sent off for a petulant kick out late on.